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rx Epitalon

A textile-layered reading of the Khavinson pineal tetrapeptide literature — Epitalon (Epithalon), AEDG, and what the studies actually measured.

the studies behind each claim

Where can you check the Epitalon papers?

The list gives each paper’s authors, journal, year, tracking number, and web address. You can see whether researchers tested cells, animals, or people.

Return to the findingsSee what this site can do

How can the numbered papers help you?

A number in brackets after a finding points to the same number below. The entry names the researchers, the journal, and the year. If I were checking a claim for you, I’d begin with the closest numbered paper. The first report tells you whether researchers used loose cells, animals, or people.

PubMed is a free list of medical papers. Much of Khavinson’s work appeared in Russian, and some papers have no English copy. Khavinson’s 2002 review [14] and Araj’s 2025 review [15] describe some of that work. The list can’t replace missing papers, but it can show you the source behind each health claim.

What details appear beside each paper?

Each entry gives the writers, journal, and year. A DOI is a lasting tracking number for one paper. A PubMed address opens the paper’s listing. Those details help you check whether a finding came from cells, animals, or people like you.

  1. Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592. ↗
  2. Al-dulaimi S, Thomas R, Matta S, Roberts T. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025. ↗
  3. Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. 2020;25(3):609. ↗
  4. Anisimov VN, Khavinson VKh, Provinciali M, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Imyanitov EN, Mancini R, Franceschi C. Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Int J Cancer. 2002;101(1):7-10. ↗
  5. Anisimov VN, Khavinson VKh, Alimova IN, Provinciali M, Mancini R, Franceschi C. Epithalon inhibits tumor growth and expression of HER-2/neu oncogene in breast tumors in transgenic mice characterized by accelerated aging. Bull Exp Biol Med. 2002;133(2):167-170. ↗
  6. Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, Zavarzina NYu, Semenchenko AV, Yashin AI. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. ↗
  7. Kossoy G, Anisimov VN, Ben-Hur H, Kossoy N, Zusman I. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo. 2006;20(2):253-257. ↗
  8. Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA. Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. Cancer Lett. 2002;183(1):1-8. ↗
  9. Anisimov VN, Popovich IG, Zabezhinski MA, Rosenfeld SV, Khavinson VKh, Semenchenko AV, Yashin AI. Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM). Vopr Onkol. 2005;51(1):93-98. ↗
  10. Vinogradova IA, Bukalev AV, Zabezhinski MA, Semenchenko AV, Khavinson VKh, Anisimov VN. Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes. Bull Exp Biol Med. 2007;144(6):825-830. ↗
  11. Korkushko OV, Khavinson VKh, Shatilo VB, Magdich LV. Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people. Bull Exp Biol Med. 2004;137(4):389-391. ↗
  12. Korkushko OV, Lapin BA, Goncharova ND, Khavinson VKh, Shatilo VB, Vengerin AA, Antoniuk-Shcheglova IA, Magdich LV. Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people. Adv Gerontol. 2007;20(1):74-85. ↗
  13. Khavinson V, Razumovsky M, Trofimova S, Grigorian R, Razumovskaya A. Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa. Neuro Endocrinol Lett. 2002;23(4):365-368. ↗
  14. Khavinson VKh. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144. ↗
  15. Araj SK, Brzezik J, Madra-Gackowska K, Szeleszczuk L. Overview of Epitalon - Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025;26(6):2691. ↗